We report a three-dimensional model of the alpha5beta1 integrin headgroup bound to the most potent and selective ligand (SJ749) known to date. The model was built using the comparative protein modeling method, and it is consistent with experimental data. From this study, we identified two potentially important regions in the alpha5beta1 receptor that are peculiar to this integrin and might be worth considering for drug targeting.
Ligand Binding Analysis for Human alfa 5 beta 1 Integrin: Strategies for Designing New alfa 5 beta 1 Integrin Antagonists / Marinelli, Luciana; A., Meyer; D., Heckmann; Lavecchia, Antonio; Novellino, Ettore; H., Kessler. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - ELETTRONICO. - 48:(2005), pp. 4204-4207. [10.1021/jm040224i]
Ligand Binding Analysis for Human alfa 5 beta 1 Integrin: Strategies for Designing New alfa 5 beta 1 Integrin Antagonists
MARINELLI, LUCIANA;LAVECCHIA, ANTONIO;NOVELLINO, ETTORE;
2005
Abstract
We report a three-dimensional model of the alpha5beta1 integrin headgroup bound to the most potent and selective ligand (SJ749) known to date. The model was built using the comparative protein modeling method, and it is consistent with experimental data. From this study, we identified two potentially important regions in the alpha5beta1 receptor that are peculiar to this integrin and might be worth considering for drug targeting.File | Dimensione | Formato | |
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