Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of the first and the second loop being substantially homologues to that of loop 1 (residues 29-38) and of loop 4 (residues 92 - 97) of NGF, respectively, displaying nerve growth factor (NGF) agonist or partial agonist activity.
HETERODIMERIC PEPTIDE COMPOUNDS DISPLAYING NGF ACTIVITY AND THEIR USE TO TREAT NEURODEGENERATIVE DISORDERS / Morelli, Giancarlo; L., Vitagliano; L., Zaccaro; E., Martegani. - (2005).
HETERODIMERIC PEPTIDE COMPOUNDS DISPLAYING NGF ACTIVITY AND THEIR USE TO TREAT NEURODEGENERATIVE DISORDERS
MORELLI, GIANCARLO;
2005
Abstract
Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of the first and the second loop being substantially homologues to that of loop 1 (residues 29-38) and of loop 4 (residues 92 - 97) of NGF, respectively, displaying nerve growth factor (NGF) agonist or partial agonist activity.File in questo prodotto:
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