A synthetic strategy to prepare o-NBS protected Fmoc-amino acids under mild conditions, in a rapid and efficient way, characterised by high yields and excellent purity of the final products has been developed. The o-NBS protected Fmoc-amino acids are employed in solid phase peptide synthesis to prepare peptidomimetics carrying mono-benzylated moieties on peptide side chains.
NEW SYNTHETIC STRATEGY FOR O-NBS PROTECTED AMINO ACIDS AND THEIR USE IN SYNTHESIS OF MONO-BENZYLATED PEPTIDES / Morelli, Giancarlo; S., DE LUCA; M. R., DELLA MOGLIE; A., DE CAPUA. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 46:(2005), pp. 6637-6640. [10.1016/j.tetlet.2005.07.154]
NEW SYNTHETIC STRATEGY FOR O-NBS PROTECTED AMINO ACIDS AND THEIR USE IN SYNTHESIS OF MONO-BENZYLATED PEPTIDES
MORELLI, GIANCARLO;
2005
Abstract
A synthetic strategy to prepare o-NBS protected Fmoc-amino acids under mild conditions, in a rapid and efficient way, characterised by high yields and excellent purity of the final products has been developed. The o-NBS protected Fmoc-amino acids are employed in solid phase peptide synthesis to prepare peptidomimetics carrying mono-benzylated moieties on peptide side chains.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
