A new and versatile on-line automated solid-phase approach to obtain cyclic PNA (I and III) and cyclic PNA-DNA chimeras (II) in highly pure form has been developed. Starting from a Tentagel matrix functionalized with a 3-chloro-4-hydroxyphenylacetic linker, the synthesis of representative, new cyclic molecules by standard peptide and phosphoramidite-based chemistry has been achieved.
Solid Phase Synthesis of cyclic PNA and PNA-DNA chimeras / L., Moggio; DE NAPOLI, Lorenzo; B., DI BLASIO; DI FABIO, Giovanni; J., Donofrio; Montesarchio, Daniela; A., Messere. - In: ORGANIC LETTERS. - ISSN 1523-7060. - ELETTRONICO. - 8:10(2006), pp. 2015-2018. [10.1021/ol0603559]
Solid Phase Synthesis of cyclic PNA and PNA-DNA chimeras
DE NAPOLI, LORENZO;DI FABIO, GIOVANNI;MONTESARCHIO, DANIELA;
2006
Abstract
A new and versatile on-line automated solid-phase approach to obtain cyclic PNA (I and III) and cyclic PNA-DNA chimeras (II) in highly pure form has been developed. Starting from a Tentagel matrix functionalized with a 3-chloro-4-hydroxyphenylacetic linker, the synthesis of representative, new cyclic molecules by standard peptide and phosphoramidite-based chemistry has been achieved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
