IRIS
SANTORO, MASSIMO
 Distribuzione geografica
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Continente #
NA - Nord America 4.339
EU - Europa 2.660
AS - Asia 816
AF - Africa 50
SA - Sud America 5
OC - Oceania 4
Continente sconosciuto - Info sul continente non disponibili 1
Totale 7.875
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Nazione #
US - Stati Uniti d'America 4.237
IT - Italia 869
CN - Cina 729
UA - Ucraina 375
IE - Irlanda 366
FI - Finlandia 324
SE - Svezia 244
DE - Germania 226
NL - Olanda 139
CA - Canada 102
GB - Regno Unito 82
CI - Costa d'Avorio 47
IN - India 35
SG - Singapore 17
IR - Iran 10
FR - Francia 9
HK - Hong Kong 8
TR - Turchia 8
ES - Italia 6
BE - Belgio 5
AU - Australia 3
KR - Corea 3
AR - Argentina 2
BG - Bulgaria 2
PL - Polonia 2
RS - Serbia 2
RU - Federazione Russa 2
ZA - Sudafrica 2
AE - Emirati Arabi Uniti 1
BD - Bangladesh 1
BO - Bolivia 1
CH - Svizzera 1
CL - Cile 1
CO - Colombia 1
CZ - Repubblica Ceca 1
DK - Danimarca 1
EG - Egitto 1
EU - Europa 1
GR - Grecia 1
IL - Israele 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
PH - Filippine 1
PK - Pakistan 1
RO - Romania 1
SK - Slovacchia (Repubblica Slovacca) 1
TW - Taiwan 1
Totale 7.875
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Città #
Chandler 762
Jacksonville 488
Millbury 344
Princeton 323
Nanjing 246
Woodbridge 212
Ashburn 158
Wilmington 147
Napoli 145
Naples 143
Amsterdam 132
Boston 113
Nanchang 97
Ottawa 90
Beijing 87
Houston 67
Ann Arbor 66
Shenyang 53
Kronberg 49
Hebei 44
Norwalk 42
Kunming 40
Tianjin 39
Boardman 38
Falls Church 38
Jiaxing 33
Des Moines 29
Changsha 27
Cagliari 24
Dublin 23
Rome 22
Nocera Superiore 18
Indiana 17
Augusta 15
Shanghai 15
Salerno 14
Washington 14
Hangzhou 12
Acerra 11
Toronto 11
Changchun 10
Lawrence 10
Little Rock 10
Milan 10
Orange 10
San Mateo 10
Leawood 9
New York 9
Pozzuoli 9
Chicago 8
Dearborn 8
Los Angeles 8
Pune 8
Redwood City 8
Santa Maria Capua Vetere 8
Seattle 8
Waldbuttelbrunn 8
Formia 7
Singapore 7
Serino 6
Zhengzhou 6
Ardabil 5
Castellammare di Stabia 5
Jinan 5
London 5
Redmond 5
San Francisco 5
Tito 5
Cleveland 4
Edinburgh 4
Fremont 4
Genoa 4
Giugliano in Campania 4
Lanzhou 4
Leiden 4
Madrid 4
Scafati 4
Sorrento 4
Yellow Springs 4
Brussels 3
Cambridge 3
Casoria 3
Fisciano 3
Jinhua 3
Lissone 3
Perugia 3
Pescara 3
Piombino 3
Portoferraio 3
San Nicola 3
Simi Valley 3
Tappahannock 3
Afragola 2
Ariano Irpino 2
Arienzo 2
Avellino 2
Bacoli 2
Baradero 2
Barano d'Ischia 2
Bari 2
Totale 4.559
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Nome #
Association between DNA methylation profile and malignancy in follicular-patterned thyroid neoplasms 115
Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase 75
UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas 67
Oncogene-induced senescence and its evasion in a mouse model of thyroid neoplasia 65
Mast cells induce epithelial-to-mesenchymal transition and stem cell features in human thyroid cancer cells through an IL-8-Akt-Slug pathway. 64
A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor 58
A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts 58
Biochemical and molecular characterization of the novel BRAF(V599Ins) mutation detected in a classic papillary thyroid carcinoma. 56
Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells. 55
RET/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase 54
20 years of RET/PTC in thyroid cancer: clinico-pathological correlations. 53
Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma 53
NCOA4 links iron bioavailability to DNA metabolism 52
NCOA4 Deficiency Impairs Systemic Iron Homeostasis 52
Molecular profile of hyalinizing trabecular tumours of the thyroid: high prevalence of RET/PTC rearrangements and absence of B-raf and N-ras point mutations 51
Thyroid targeting of the N-ras(Gln61Lys) oncogene in transgenic mice results in follicular tumors that progress to poorly differentiated carcinomas. 51
Signal Transducer and Activator of Transcription 1 Plays a Pivotal Role in RET/PTC3 Oncogene-induced Expression of Indoleamine 2,3-Dioxygenase 1 51
The importance of the RET gene in thyroid cancer and therapeutic implications 51
Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis 50
Mast cells have a protumorigenic role in human thyroid cancer. 50
Analisi del profilo di espressione di microRNA nella senescenza cellulare 50
Bioisosteric discovery of npa101.3, a second-generation ret/vegfr2 inhibitor optimized for single-agent polypharmacology 50
BAY 43-9006 inhibition of oncogenic RET mutants 49
45th Annual Meeting of the Italian Cancer Society 49
An adenovirus carrying the rat protein tyrosine phosphatase eta suppresses the growth of human thyroid carcinoma cell lines in vitro and in vivo. 48
Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene. 48
Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology 48
The molecular basis for RET tyrosine-kinase inhibitors in thyroid cancer 48
Thyroid cell transformation inhibits the expression of a novel rat protein tyrosine phosphatase. 47
BRAF is a therapeutic target in aggressive thyroid carcinoma. 46
Identification of a chimeric gene frequently activated in human thyroid papillary carcinomas 46
Point mutation in GRIM-19: a new genetic lesion in Hurthle cell thyroid carcinomas 46
The rat tyrosine phosphatase eta increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue. 45
A new mechanism of BRAF activation in human thyroid papillary carcinomas 45
A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma. 43
The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes 43
The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells. 43
I geni oncosoppressori in "Patologia Generale" IV Ed, Pontieri-Russo-Frati 42
Extracellular superoxide dismutase is a thyroid differentiation marker downregulated in cancer. 42
Neoplastic transformation of rat thyroid cells requires the JunB and Fra1 gene induction which is dependent on the HMGI-C gene products. 41
Rnf4 is a growth inhibitor expressed in germ cells but not in human testicular tumors 41
Activation of RET oncogene and thyroid carcinogenesis 41
Signaling pathways and mechanism of action of the extracellular superoxide dismutase, SOD3. 41
Attacking cancer with molecularly targeted agents 41
NCOA4 inhibits initiation of DNA replication to maintain genome stability 40
null 39
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. 39
Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells. 39
A dual mechanism of activation of the sonic hedgehog pathway in anaplastic thyroid cancer: Crosstalk with RAS-BRAF-MEK pathway and ligand secretion by tumor stroma 39
Chromatin and DNA methylation dynamics during retinoic acid-induced RET gene transcriptional activation in neuroblastoma cells. 38
A potential pathogenetic mechanism for multiple endocrine neoplasia type 2 syndromes involves ret-induced impairment of terminal differentiation of neuroepithelial cells. 38
A mutated p53 gene alters thyroid cell differentiation 38
NCOA4 transcriptional coactivator inhibits activation of DNA replication origins. 38
Genetics: The genomic landscape of papillary thyroid carcinoma 38
Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases 38
Specific microRNAs are downregulated in human thyroid anaplastic carcinomas. 37
The oncogenic activity of RET point mutants for follicular thyroid cells may account for the occurrence of papillary thyroid carcinoma in patients affaected by familial medullary thyroid carcinoma. 37
Molecular cloning of PTC,a new oncogene found activated in human thyiroid papillary carcinomas and their lymph node metastates 37
A TSH-CREB1-microRNA loop is required for thyroid cell growth. 37
Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma 37
Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application 37
A novel pathway of cell growth regulation mediated by a PLA2alpha-derived phosphoinositide metabolite. 36
Akt/protein kinase B promotes survival and hormone-independent proliferation of thyroid cells in the absence of dedifferentiating and transforming effects 36
Activation of RET as a dominant transforming gene by germline mutatios of MEN2A and MEN2B 36
The PTC oncogene is able to dedifferentiate a rat thyroid epithelial cell line in culture 36
Activated RET oncogene products induce maturation of xenopus oocytes. 36
The RET kinase inhibitor NVP-AST487 blocks growth and calcitonin gene expression through distinct mechanisms in medullary thyroid cancer cells 35
Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas 35
Morphological ultrasound micro-imaging of thyroid in living mice. 35
Central role of RET in thyroid cancer 35
A truncated HMGA1 gene induces proliferation of the 3T3-L1 pre-adipocytic cells: a model of human lipomas. 34
A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases 34
Thyroid carcinomas induction by mutations of the RET oncoprotein 34
SOD3 decreases ischemic injury derived apoptosis through phosphorylation of Erk1/2, Akt, and FoxO3a. 34
Novel candidate genes of thyroid tumourigenesis identified in Trk-T1 transgenic mice. 34
FOXM1 is a molecular determinant of the mitogenic and invasive phenotype of anaplastic thyroid carcinoma. 34
NCOA4 Links Iron Bioavailability to DNA Metabolism 34
MicroRNA deregulation in human thyroid papillary carcinomas. 33
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture. 33
Structure and chemical inhibition of the RET tyrosine kinase domain. 33
ASSOCIATION OF BRAF V600E MUTATION WITH POOR CLINICOPATHOLOGICAL OUTCOMES IN 500 CONSECUTIVE CASES OF PAPILLARY THYROID CARCINOMA. 33
Overexpression of the Cytokine Osteopontin Identifies Aggressive Laryngeal Squamous Cell Carcinomas and Enhances Carcinoma Cell Proliferation and Invasiveness. 33
The Ca2+-calmodulin dependent kinase II (CaMKII) is activated in papillary thyroid carcinoma and mediates cell proliferation stimulated by RET/PTC. 33
RET/papillary thyroid cancer rearrangement in nonneoplastic thyrocytes:follicular cells of Hashimoto's thyroiditis share low-level recombination events 32
Loss of p27 Expression Through RAS-->BRAF-->MAP Kinase-Dependent Pathway in Human Thyroid Carcinomas. 32
ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases 32
Thyroid cell transformation:the role of ras oncogene in vivo e in vitro 32
Receptor- and non-receptor tyrosine kinases induce processing of the amyloid precursor protein: role of the low-density lipoprotein receptor-related protein. 32
Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines. 32
Osteopontin is overexpressed in human papillary thyroid carcinomas and enhances thyroid carcinoma cell invasiveness 31
Drug insight: Small-molecule inhibitors of protein kinases in the treatment of thyroid cancer. 31
Receptor tyrosine kinases as targets for anticancer therapeutics 31
RET 31
Basi molecolari delle nuove terapie: inibitori delle protein-chinasi. 31
The receptor tyrosine kinase RET is a Hsp90 client protein and is degraded upon exposure to 17-AAG. 31
A new germline RET mutation apparently devoid of transforming activity serendipitously discovered in a patient with atrophic autoimmune thyroiditis and primary ovarian failure. 31
Tumor Suppressor Role of the CL2/DRO1/CCDC80 Gene in Thyroid Carcinogenesis 31
Ret gene fusions in malignancies of the thyroid and other tissues 31
Mitogenic effects of the up-regulation of minichromosome maintenance proteins in anaplastic thyroid carcinoma 30
Thyroid cell transformation requires the expression of the HMGA1 proteins 30
Totale 4.197
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Categoria #
all - tutte 32.691
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 32.691
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/201971 0 0 0 0 0 0 0 0 0 20 20 31
2019/2020987 386 20 80 23 93 13 19 8 8 62 117 158
2020/20211.034 14 93 144 92 87 179 80 21 113 25 171 15
2021/20221.678 32 24 18 13 23 62 32 72 374 76 255 697
2022/20231.878 352 113 21 203 194 224 6 189 297 149 98 32
2023/2024909 50 193 168 91 65 103 32 163 29 15 0 0
Totale 8.198