Sfoglia per Autore
The Crosstalk between N-Formyl Peptide Receptors and uPAR in Systemic Sclerosis: Molecular Mechanisms, Pathogenetic Role and Therapeutic Opportunities
2024 Napolitano, Filomena; Rossi, Francesca Wanda; de Paulis, Amato; Lavecchia, Antonio; Montuori, Nunzia
Identification of selective 5-LOX and FLAP inhibitors as novel anti-inflammatory agents by ligand-based virtual screening
2024 Cerchia, Carmen; Küfner, Laura; Werz, Oliver; Lavecchia, Antonio
New avenues in artificial-intelligence-assisted drug discovery
2023 Cerchia, Carmen; Lavecchia, Antonio
In Silico Drug Design and Discovery: Big Data for Small Molecule Design
2023 Cerchia, C.; Lavecchia, A.
Novel Reversible Inhibitors of Xanthine Oxidase Targeting the Active Site of the Enzyme
2023 Rullo, Rosario; Cerchia, Carmen; Nasso, Rosarita; Romanelli, Virgilio; DE VENDITTIS, Emmanuele; Masullo, Mariorosario; Lavecchia, Antonio
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition
2023 Laghezza, Antonio; Cerchia, Carmen; Genovese, Massimo; Leuci, Rosalba; Pranzini, Erica; Santi, Alice; Brunetti, Leonardo; Piemontese, Luca; Tortorella, Paolo; Biswas, Abanish; Pratap Singh, Ravi; Tambe, Suhas; Ca, Sudeep; Kumar Pattnaik, Ashok; Jayaprakash, Venkatesan; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio
Activation of Non-Canonical Autophagic Pathway through Inhibition of Non-Integrin Laminin Receptor in Neuronal Cells
2022 Limone, Adriana; Veneruso, Iolanda; Izzo, Antonella; Renna, Maurizio; Bonavita, Raffaella; Piscitelli, Silvia; Calì, Gaetano; De Nicola, Sergio; Riccio, Patrizia; D’Argenio, Valeria; Lavecchia, Antonio; Sarnataro, Daniela
Current status and future prospects of molecular hybrids with thiazolidinedione (TZD) scaffold in anticancer drug discovery
2022 Tilekar, K.; Shelke, O.; Upadhyay, N.; Lavecchia, A.; Ramaa, C. S.
In Silico Identification of Novel Inhibitors Targeting the Homodimeric Interface of Superoxide Dismutase from the Dental Pathogen Streptococcus mutans
2022 Cerchia, Carmen; Roscetto, Emanuela; Nasso, Rosarita; Catania, Maria Rosaria; De Vendittis, Emmanuele; Lavecchia, Antonio; Masullo, Mariorosario; Rullo, Rosario
A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity
2022 Sblano, Sabina; Cerchia, Carmen; Laghezza, Antonio; Piemontese, Luca; Brunetti, Leonardo; Leuci, Rosalba; Gilardi, Federica; Thomas, Aurelien; Genovese, Massimo; Santi, Alice; Tortorella, Paolo; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio
Impairment of Nucleolin Activity and Phosphorylation by a Trachylobane Diterpene from Psiadia punctulata in Cancer Cells
2022 Bellone, M. L.; Fiengo, L.; Cerchia, C.; Cotugno, R.; Bader, A.; Lavecchia, A.; De Tommasi, N.; Piaz, F. D.
Antagonizing S1P3 receptor with Cell-Penetrating Pepducins in Skeletal Muscle Fibrosis
2021 Scognamiglio, Antonia; Corvino, Angela; Esposito, Gianluca; Esposito, Giovanna; Santagada, Vincenzo; Lavecchia, Antonio; LO BIANCO, Alessandra; Roviezzo, Fiorentina; Donati, Chiara; Severino, Beatrice
Thiazolidinedione "magic Bullets" Simultaneously Targeting PPARγand HDACs: Design, Synthesis, and Investigations of their in Vitro and in Vivo Antitumor Effects
2021 Tilekar, K.; Hess, J. D.; Upadhyay, N.; Bianco, A. L.; Schweipert, M.; Laghezza, A.; Loiodice, F.; Meyer-Almes, F. -J.; Aguilera, R. J.; Lavecchia, A.; Ramaa, C. S.
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects
2021 Yasmin, S.; Cerchia, C.; Badavath, V. N.; Laghezza, A.; Dal Piaz, F.; Mondal, S. K.; Atli, O.; Baysal, M.; Vadivelan, S.; Shankar, S.; Siddique, M. U. M.; Pattnaik, A. K.; Singh, R. P.; Loiodice, F.; Jayaprakash, V.; Lavecchia, A.
HDAC4 Inhibitors with Cyclic Linker and Non-hydroxamate Zinc Binding Group: Design, Synthesis, HDAC Screening and in vitro Cytotoxicity evaluation
2021 Tilekar, K.; Hess, J. D.; Upadhyay, N.; Schweipert, M.; Flath, F.; Gutierrez, D. A.; Loiodice, F.; Lavecchia, A.; Meyer-Almes, F. -J.; Aguilera, R. J.; Ramaa, C. S.
Discovery of a Novel Inhibitor of Human Purine Nucleoside Phosphorylase by a Simple Hydrophilic Interaction Liquid Chromatography Enzymatic Assay
2021 Rabuffetti, M.; Rinaldi, F.; Lo Bianco, A.; Speranza, G.; Ubiali, D.; de Moraes, M. C.; Rodrigues Pereira da Silva, L. C.; Massolini, G.; Calleri, E.; Lavecchia, A.
Antagonizing S1P3 receptor with cell-penetrating pepducins in skeletal muscle fibrosis
2021 Corvino, A.; Cerqua, I.; Lo Bianco, A.; Caliendo, G.; Fiorino, F.; Frecentese, F.; Magli, E.; Morelli, E.; Perissutti, E.; Santagada, V.; Cirino, G.; Granato, E.; Roviezzo, F.; Puliti, E.; Bernacchioni, C.; Lavecchia, A.; Donati, C.; Severino, B.
Pharmacophore hybridization approach to discover novel pyrazoline-based hydantoin analogs with anti-tumor efficacy
2021 Upadhyay, N.; Tilekar, K.; Loiodice, F.; Anisimova, N. Y.; Spirina, T. S.; Sokolova, D. V.; Smirnova, G. B.; Choe, J. -Y.; Meyer-Almes, F. -J.; Pokrovsky, V. S.; Lavecchia, A.; Ramaa, C. S.
App maturation and intracellular localization are controlled by a specific inhibitor of 37/67 kda laminin-1 receptor in neuronal cells
2020 Bhattacharya, A.; Limone, A.; Napolitano, F.; Cerchia, C.; Parisi, S.; Minopoli, G.; Montuori, N.; Lavecchia, A.; Sarnataro, D.
Sulfonimide and amide derivatives as novel PPARα antagonists: Synthesis, antiproliferative activity, and docking studies
2020 Ammazzalorso, A.; Bruno, I.; Florio, R.; de Lellis, L.; Laghezza, A.; Cerchia, C.; de Filippis, B.; Fantacuzzi, M.; Giampietro, L.; Maccallini, C.; Tortorella, P.; Veschi, S.; Loiodice, F.; Lavecchia, A.; Cama, A.; Amoroso, R.
| Titolo | Tipologia | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|---|
| The Crosstalk between N-Formyl Peptide Receptors and uPAR in Systemic Sclerosis: Molecular Mechanisms, Pathogenetic Role and Therapeutic Opportunities | 1.1 Articolo in rivista | 2024 | Napolitano, Filomena; Rossi, Francesca Wanda; de Paulis, Amato; Lavecchia, Antonio; Montuori, Nunzia | |
| Identification of selective 5-LOX and FLAP inhibitors as novel anti-inflammatory agents by ligand-based virtual screening | 1.1 Articolo in rivista | 2024 | Cerchia, Carmen; Küfner, Laura; Werz, Oliver; Lavecchia, Antonio | |
| New avenues in artificial-intelligence-assisted drug discovery | 1.1 Articolo in rivista | 2023 | Cerchia, Carmen; Lavecchia, Antonio | |
| In Silico Drug Design and Discovery: Big Data for Small Molecule Design | 1.1 Articolo in rivista | 2023 | Cerchia, C.; Lavecchia, A. | |
| Novel Reversible Inhibitors of Xanthine Oxidase Targeting the Active Site of the Enzyme | 1.1 Articolo in rivista | 2023 | Rullo, Rosario; Cerchia, Carmen; Nasso, Rosarita; Romanelli, Virgilio; DE VENDITTIS, Emmanuele; Masullo, Mariorosario; Lavecchia, Antonio | |
| A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition | 1.1 Articolo in rivista | 2023 | Laghezza, Antonio; Cerchia, Carmen; Genovese, Massimo; Leuci, Rosalba; Pranzini, Erica; Santi, Alice; Brunetti, Leonardo; Piemontese, Luca; Tortorella, Paolo; Biswas, Abanish; Pratap Singh, Ravi; Tambe, Suhas; Ca, Sudeep; Kumar Pattnaik, Ashok; Jayaprakash, Venkatesan; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio | |
| Activation of Non-Canonical Autophagic Pathway through Inhibition of Non-Integrin Laminin Receptor in Neuronal Cells | 1.1 Articolo in rivista | 2022 | Limone, Adriana; Veneruso, Iolanda; Izzo, Antonella; Renna, Maurizio; Bonavita, Raffaella; Piscitelli, Silvia; Calì, Gaetano; De Nicola, Sergio; Riccio, Patrizia; D’Argenio, Valeria; Lavecchia, Antonio; Sarnataro, Daniela | |
| Current status and future prospects of molecular hybrids with thiazolidinedione (TZD) scaffold in anticancer drug discovery | 1.1 Articolo in rivista | 2022 | Tilekar, K.; Shelke, O.; Upadhyay, N.; Lavecchia, A.; Ramaa, C. S. | |
| In Silico Identification of Novel Inhibitors Targeting the Homodimeric Interface of Superoxide Dismutase from the Dental Pathogen Streptococcus mutans | 1.1 Articolo in rivista | 2022 | Cerchia, Carmen; Roscetto, Emanuela; Nasso, Rosarita; Catania, Maria Rosaria; De Vendittis, Emmanuele; Lavecchia, Antonio; Masullo, Mariorosario; Rullo, Rosario | |
| A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity | 1.1 Articolo in rivista | 2022 | Sblano, Sabina; Cerchia, Carmen; Laghezza, Antonio; Piemontese, Luca; Brunetti, Leonardo; Leuci, Rosalba; Gilardi, Federica; Thomas, Aurelien; Genovese, Massimo; Santi, Alice; Tortorella, Paolo; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio | |
| Impairment of Nucleolin Activity and Phosphorylation by a Trachylobane Diterpene from Psiadia punctulata in Cancer Cells | 1.1 Articolo in rivista | 2022 | Bellone, M. L.; Fiengo, L.; Cerchia, C.; Cotugno, R.; Bader, A.; Lavecchia, A.; De Tommasi, N.; Piaz, F. D. | |
| Antagonizing S1P3 receptor with Cell-Penetrating Pepducins in Skeletal Muscle Fibrosis | 4.3 Poster | 2021 | Scognamiglio, Antonia; Corvino, Angela; Esposito, Gianluca; Esposito, Giovanna; Santagada, Vincenzo; Lavecchia, Antonio; LO BIANCO, Alessandra; Roviezzo, Fiorentina; Donati, Chiara; Severino, Beatrice | |
| Thiazolidinedione "magic Bullets" Simultaneously Targeting PPARγand HDACs: Design, Synthesis, and Investigations of their in Vitro and in Vivo Antitumor Effects | 1.1 Articolo in rivista | 2021 | Tilekar, K.; Hess, J. D.; Upadhyay, N.; Bianco, A. L.; Schweipert, M.; Laghezza, A.; Loiodice, F.; Meyer-Almes, F. -J.; Aguilera, R. J.; Lavecchia, A.; Ramaa, C. S. | |
| A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects | 1.1 Articolo in rivista | 2021 | Yasmin, S.; Cerchia, C.; Badavath, V. N.; Laghezza, A.; Dal Piaz, F.; Mondal, S. K.; Atli, O.; Baysal, M.; Vadivelan, S.; Shankar, S.; Siddique, M. U. M.; Pattnaik, A. K.; Singh, R. P.; Loiodice, F.; Jayaprakash, V.; Lavecchia, A. | |
| HDAC4 Inhibitors with Cyclic Linker and Non-hydroxamate Zinc Binding Group: Design, Synthesis, HDAC Screening and in vitro Cytotoxicity evaluation | 1.1 Articolo in rivista | 2021 | Tilekar, K.; Hess, J. D.; Upadhyay, N.; Schweipert, M.; Flath, F.; Gutierrez, D. A.; Loiodice, F.; Lavecchia, A.; Meyer-Almes, F. -J.; Aguilera, R. J.; Ramaa, C. S. | |
| Discovery of a Novel Inhibitor of Human Purine Nucleoside Phosphorylase by a Simple Hydrophilic Interaction Liquid Chromatography Enzymatic Assay | 1.1 Articolo in rivista | 2021 | Rabuffetti, M.; Rinaldi, F.; Lo Bianco, A.; Speranza, G.; Ubiali, D.; de Moraes, M. C.; Rodrigues Pereira da Silva, L. C.; Massolini, G.; Calleri, E.; Lavecchia, A. | |
| Antagonizing S1P3 receptor with cell-penetrating pepducins in skeletal muscle fibrosis | 1.1 Articolo in rivista | 2021 | Corvino, A.; Cerqua, I.; Lo Bianco, A.; Caliendo, G.; Fiorino, F.; Frecentese, F.; Magli, E.; Morelli, E.; Perissutti, E.; Santagada, V.; Cirino, G.; Granato, E.; Roviezzo, F.; Puliti, E.; Bernacchioni, C.; Lavecchia, A.; Donati, C.; Severino, B. | |
| Pharmacophore hybridization approach to discover novel pyrazoline-based hydantoin analogs with anti-tumor efficacy | 1.1 Articolo in rivista | 2021 | Upadhyay, N.; Tilekar, K.; Loiodice, F.; Anisimova, N. Y.; Spirina, T. S.; Sokolova, D. V.; Smirnova, G. B.; Choe, J. -Y.; Meyer-Almes, F. -J.; Pokrovsky, V. S.; Lavecchia, A.; Ramaa, C. S. | |
| App maturation and intracellular localization are controlled by a specific inhibitor of 37/67 kda laminin-1 receptor in neuronal cells | 1.1 Articolo in rivista | 2020 | Bhattacharya, A.; Limone, A.; Napolitano, F.; Cerchia, C.; Parisi, S.; Minopoli, G.; Montuori, N.; Lavecchia, A.; Sarnataro, D. | |
| Sulfonimide and amide derivatives as novel PPARα antagonists: Synthesis, antiproliferative activity, and docking studies | 1.1 Articolo in rivista | 2020 | Ammazzalorso, A.; Bruno, I.; Florio, R.; de Lellis, L.; Laghezza, A.; Cerchia, C.; de Filippis, B.; Fantacuzzi, M.; Giampietro, L.; Maccallini, C.; Tortorella, P.; Veschi, S.; Loiodice, F.; Lavecchia, A.; Cama, A.; Amoroso, R. |
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